Sublingual buprenorphine used postoperatively: ten hour plasma drug concentration analysis.
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چکیده
منابع مشابه
Subnanogram-concentration measurement of buprenorphine in human plasma by electron-capture capillary gas chromatography: application to pharmacokinetics of sublingual buprenorphine.
We describe a sensitive and specific method for the measurement of buprenorphine in human plasma. The method involves a structural analog as an internal calibrator, careful control of pH during sample extraction to maximize drug recovery, and back-extraction into acid followed by reextraction to eliminate endogenous interferences. After evaporation, sample residues are derivatized with heptaflu...
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AIM The aims of this study were to perform clinicopathological analyses of teratoid cysts of the floor of the mouth and to assess the possibility of surgical treatment. MATERIALS AND METHODS The incidence, manifestations, histogenesis, treatment and prognosis of 10 patients admitted to our department between April 2000 and May 2008 were reviewed. RESULTS Teratoid cysts occurred almost ex...
متن کاملThe Pharmacokinetics and Local Tolerability of a Novel Sublingual Formulation of Buprenorphine.
Aim The principal study objective was to investigate the pharmacokinetic characteristics and determine the absolute bioavailability and tolerability of a new sublingual (SL) buprenorphine wafer. Methods The study was of open label, two-way randomized crossover design in 14 fasted healthy male and female volunteers. Each participant, under naltrexone block, received either a single intravenous...
متن کاملBuprenorphine implants for treatment of opioid dependence: randomized comparison to placebo and sublingual buprenorphine/naloxone.
AIMS To evaluate the safety and efficacy of buprenorphine implants (BI) versus placebo implants (PI) for the treatment of opioid dependence. A secondary aim compared BI to open-label sublingual buprenorphine/naloxone tablets (BNX). DESIGN Randomized, double-blind, placebo-controlled trial. Subjects received either four buprenorphine implants (80 mg/implant) (n = 114), four placebo implants (n...
متن کاملEfficacy of Buprenorphine/Naloxone Rapidly Dissolving Sublingual Tablets (BNX-RDT) After Switching From BNX Sublingual Film
OBJECTIVES The aim of the study was to evaluate treatment retention, efficacy, and preference ratings among opioid-dependent patients transitioning between a buprenorphine/naloxone rapidly dissolving sublingual tablet formulation (BNX-RDT) and BNX film. METHODS After a 2-day, blinded, fixed-dose induction with BNX-RDT (5.7/1.4 mg and 5.7/1.4 or 11.4/2.8 mg, respectively) or buprenorphine (8 m...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1982
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1982.tb01434.x